I don't use Unraid, but I have been following this thread and thought I would share my experience of the X11SCA-F with ESXi 7.
After a lot of tinkering, I have managed concurrent use of iKVM and the passthrough of onboard iGPU and 2x graphics cards (RTX 4000 & T1000).
BIOS 1.2 (X11SCA9.C05):
Load Optimised Defaults
Primary Display = PCI
Primary PEG = Slot 4 (RTX 4000)
Primary PCI = Onboard
Internal Graphics = Enabled
>then last, set the following:
Option ROM, Video = UEFI
save & reset
server starts to POST and before completing, it reboots once, then boots fully into ESXi and is fine after
I needed to activate the passthrough of the 'Processor Gaussian Mixture Model' PCI device to allow the 2nd GPU to remain Active, which was odd, but not a problem. All persists on reboot. IPMI version 01.73.13.
I had this working a year ago with a Quadro P4000 and P620, but in an attempt to resolve an NVMe issue, I removed the GPUs, upgraded the BIOS to the current 1.6a and tried several other changes, but was not successful. I then installed my newer GPUs ...and entered the world blank screens and CMOS resets noted by others. With BIOS 1.6a, I had managed to get iKVM, iGPU and a single GPU to work using the settings above, but keeping the Video Option ROM = Legacy. For 2 GPUs I needed to revert to my last known working BIOS 1.2. I have a few BIOS files between 1.2 and 1.6a, so I could try these, but as it works now, I probably won't bother.
X11SCA-F PCI slots:
Slot 7: Broadcom 9400-16i (16x HDD) - Passthrough to OmniOS
Slot 6: AOC-SHG3-4M2P (3x M.2-NVMe & 1x M.2-PCIe) - Local
Slot 5: USB-C from motherboard header
Slot 4: Nvidia Quadro RTX 4000 - Passthrough to Win VM (disable before VM shutdown)
Slot 3: gap
Slot 2: Nvidia T1000 - Passthrough to Win VM (Parsec only, no Gamestream)
Slot 1: Intel X20-DA2 10Gbe NIC (PCIe cable to AOC-SHG3-4M2P) - Local
M.2-2: Intel Optane 900P - Local
AHCI: SSDs - Local
iGPU: UHD P630 - Passthrough to Win VM