Solved, for searchability maybe it helps someone else.
Motherboard: Rog Strix B450-F Gaming II
CPU: Ryzen 5 4500
SATA Ports 5 & 6 turn off when m.2_1 is operating in sata or pcie mode. Solution setM.2_1 to "sata56"
My second external SATA controller is a PCIEx1 and the PCIEx16_3 controller needed to be set from Auto to "x1 Mode".
See screenshot.
still having issues with Ryzen 5 4500 onboard graphics wont output on the HDMI, i want to remove the gpu eventually to conserve power. I do not find an option for graphics in the bios like i did with Intel board. my First ryzen Cpu.
EDIT: seems ryzen 5 4500 does not include a CPU graphics, so i have to keep the card.
