Here is some more details.
I'm running Unraid on a Dell r510. Comes with PERC H700 (which I know is frowned upon. However, this was for my initial test run). I set each drive up to RAID 0 so that each drive could be seen individually by Unraid. In total, I have 9 2TB drives and a couple of SSDs for the cache. It has been running fine for about 11 months. Recently, one of the disks started throwing some errors. I figured I'd just swap out that disk for another. I stopped the array, removed the drive, and restarted the drive. This is when I got the first "device missing" message. However, I was still able to start the array.
I decided to dig a little deeper today and see if there was something else going on. I got into the BIOS, and a couple of the drives were reported "offline". I removed one, and put a spare that I had in the same slot, and the BIOS showed the drive in a "ready" state. I concluded that the "offline" drives have completely failed.
I figured I was still fine, since my cache, parity and 2 array drives were still operational (as seen in the screenshot). So I'm a little perplexed as to why the array wouldn't start.
Hopefully, that cleared it up a bit...