VM is unresponsive even in ssh or remote access? If yes, you should check if the vm is paused (Out space in disk most of the times), you should check if it is when the computer turn off the display and won't turn on again and disable in windows or the operation system you use, and then check with another gpu or without gpu if you can if happens the same, with other cpu cores, if it still happens after tested everything you can, you need to analyse your VM config (That is very unique so i can't help much with my knowledge)