Replace External Hard Drive (Unassigned Devices)

I have an external drive connected via a usb port on the motherboard.  It's currently mounted through the unassigned devices plugin.  For the past few months the reallocated sector count has been increasing daily if not every other day.  The reallocated sector count is just over 600.  I believe the drive will die soon.  My question is, to replace the drive, do I just unmount the drive, turn off the server and connect a new drive in the same usb slot on the motherboard?  Will I have to remap any directories to the new drive that other apps might have in place?  Thanks.