CPU and Memory are maxing, driving up i/o on cache drive

[Eviseration]

I have been running into situations where I get a notification that my nvme drive (which I used for my cache pool) is overheating.  When I log into my system, all CPUs are maxed out, Memory is maxed out (which is normally at about 40%). Basically, something is causing the system to redline itself.  This requires a forced reboot to clear it (shutdown won't even respond).  This happened again today.  Can anyone think of anything that could be causing this?  I do have a windows VM and Docker containers running and I know I need to upload logs to really figure out the issue (I neglected to download the diagnostics before rebooting so I'm assuming anything helpful for figuring this out is lost.  I'm running 6.11.5.

 

If anyone has any hits on what I should collect the next time this happens (which will probably be next week), I'll make sure I collect everything before rebooting.