So I finally upgraded to the latest release after not doing it for 4 years. I had wireguard setup and working just fine. Now nothing about it works. If I have it on, my nginxproxymanager stops working and my domains do not point to dockers. Also, while connected remotely I cannot access websites. I can access my local LAN but that is it. If I turn the wireguard tunnel off my domains start working again. Where the hell do I start with this?

Thanks guys!

I do not have any custom networks setup other then wireguard. Nothing is making sense to me. My server is remote and I dont have access to it. This is very disheartening. I also cannot download any plugins via the apps. I am at a loss here.

I am still stuck here. Wireguard not working anymore

Did you try creating a new tunnel to see if that works?