All right, I got things working.    Starting with Python 3.10, OpenSSL 1.1.1 or newer is required https://peps.python.org/pep-0644/ which means the OpenSSL 1.1 installed by default in Unraid 6.12.3 does not meet the requirements. In other words, using Python 3.10 or newer will require OpenSSL to also be installed as a prerequisite. I got OpenSSL 3.1.2 from https://slackware.uk/slackware/slackware64-current/slackware64/n/openssl-3.1.2-x86_64-1.txz and added it to the /boot/extra/ direct