Application Name: Pydio
Application Site: https://pyd.io/
Docker Hub: https://hub.docker.com/r/linuxserver/pydio/
Github: https://github.com/linuxserver/docker-pydio
Please post any questions/issues relating to this docker you have in this thread.
If you are not using Unraid (and you should be!) then please do not post here, instead head to linuxserver.io to see how to get support.
My suspicions were correct. Setting up a domain in the form of pydio.server.com and using the below config will work out the box with a fresh pydio install. So that's going to be my advice. It does tend to work better with apps like this and nextcloud.
<VirtualHost *:80>
ServerName pydio.server.com
ServerAlias pydio.server.com
DocumentRoot /config/www/
Redirect permanent / https://pydio.server.com/
</VirtualHost>
<VirtualHost *:443>
ServerName pydio.server.com
Serve