Update.   Managed to achieve isolating Docker/VMs in the end thanks to the following threads:       Essentially your second/third/forth NIC needs to be set as follows in UnRAID's network settings:   UnRAID Network Settings Enable bonding: No Enable bridging: No IPv4 address assignment: None   UnRAID Docker Settings (Example) - Use your own IP ranges. Subnet: 10.10.2.0/24 Gateway: 10.10.2.1 DHCP pool: 10.10.2.100/27