after trouble shooting, it is confirmed this issue is due to same IPv6 subnet in same ethernet interfaces (eth0, eth1, eth2) and docker bridge turned on.
When finish the network setting, same IPv6 subnet in different interfaces just fine, no disorder happen. Then once I turned docker on with bridge enabled in these interfaces. The network setting page just run into chaos.
So the final solution is reconfigure the network according to JorgeB's suggestion and avoid same IPv6 subnet in different interfaces if they are used for docker bridge network.
