Advice on disks configuration, first time user

Hi all, I'm currently building my first Unraid server, and I'd like some advice on how to configure my storage (Array vs ZFS Pool, which disks, etc.).

Keep in mind that i'm moving from a Synology 2-bay array: 2x8Tb WD RED Plus using their BTRFS + Synology Hybrid RAID-1 (with 2 disks it's effectively just a mirror).

I've purchased a new computer (parts are still arriving) with the intent of consolidating a few other things that are running in other machines with a single server, with VMs and Docker containers. There's plenty (~10) of drive bays available + M2 slots.

When all is here I would have for storage:

• 2x 1TB WD Blue NVME that i just purchased (but could still return)

• 2x 8TB WD RED Plus (currently in NAS, used at about 50% )

• 3TB WD RED plus

• 1TB WD Red plus

• 2-3 other SATA Disks, < 1 TB, old consumer grade stuff from a decade ago that I have lying around and stopped using since I had a NAS

How should I organize my disks / partitions? I'm a bit confused because of all the possible choices. Unraid array to use different disk sizes? ZFS pool? NVME storage to be assigned directly to VMs? Keep also in mind that I have an offsite backup for all the things i really don't want to lose (photos of the last 20 years, roughly).