From what I've seen people posting, no problems with AMD and Unraid.. not to say that there may not be an issue here or there, just seems like nobody is having major problems.   Never used Blue Iris so can't comment, but if you need some GPU ability for it then you might want to stick with what you know will work.  Otherwise then yeah you might need more than one GPU if it needs a dedicated card and then you want GPU somewhere else also... that seems like it could get pretty messy.
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