For the record I have this similar problem and was googling around these forums, reddit... and plex forums.
In my case, the official plex docker is the clear culprit, stopping it practically starves the loop2. Installing other alternatives (linuxserver) radically lowers the amount of writes.
https://www.reddit.com/r/unRAID/comments/ea85gc/high_disk_writes_with_official_plex_docker_in/
https://forums.plex.tv/t/pms-docker-unraid-is-constantly-writing-to-its-docker-home-library/419895
Now the numbers: (from iotop -oa -d 60 and collect 1 minute), I start the respective docker a couple minutes beforehand to discount spawning read/writes
No plex docker active: 58M Writen by loop2 => 81 GB/day
Official plex running: 387M Writen by loop2 => 0.5 TB/day
linuxserver/plex running: 36M Written by loop2 => 50 GB/day
(Clearly there are other things writing around meanwhile, but there is a comfortable factor ~10 difference by not using the official plex docker.
So, I advice everybody to check their cache usage if using plex, and possibly gain years of life on your SSDs. You can simply point to the old appdata folder in the advanced docker configuration to save reconfiguring and watch progress. I imagine is a very good idea to NOT have both dockers running at the same time (I have and will not try).
(I would also advice unraid devs to place some kind of warning regarding these kind SSD killer issues?).