Just woke up to these same symptoms, minus any visible NIC bounces. Some docker services were up fine, some were partially usable. VMs appeared to be inaccessible. Ran HDMI and USB cables into the closet and found some IO errors, I assume on the flash drive. (Really wish we could do away with installations to fragile flash media.) Waited a few min for my shutdown attempt then just hit the power switch and yanked the flash drive to make a backup. Hope it's repairable, but I have backups on the array as well.