ESXi supports RDM (Raw Device Mapping) for hard drives without VT-d, up to 2TB for VM 8, and >2TB for VM 10. Since the only way to manage VM10 machines running on ESXi is to use vSphere Web Client (which is overkill for a single server like mine), I am still using VM 8, which, again only supports 2TB drives in RDM and smaller. HOWEVER, ESXi 5.5 supports VMDK of >2TB, so my 2TB drives are RDM and my 4TB drive is using VMDK. Kind of a frankenserver but I can't spin my wheels much longer with this, and I don't have to buy a VT-d processor in order for it to work.
This could all work with unRaid as far as I can tell, without the need for VT-d. From my reading you don't need VT-d for PCI Passthrough with XenServer as long as the guest is paravirtualized, which unRAID is. You just need to compile the pciback module with the unRAID kernel. Hopefully Grumpy will do that for the future. In fact, PV guests not needing VT-d was the MAIN reason I scrapped my ESXi server and tried to go with XenServer. For now I'll use my Server Essentials 2012 R2 license with storage spaces for my NAS. Overkill, yes, but I got it working rather quickly. Someday I will be able to give unRAID a shot and I look forward to it.