I'm running the following:
Gigabyte GA-EP45-UD3P
Intel Quad-Core Q6600 2.4GHz CPU
2 Norco SS500
4 x WD750GB
4 x WD500GB
4GB RAM
Rosewill PCIe 4xSATA CARD
Cooler Master 590 CASE
Corsair 650W power supply
An OLD ATI video card
Kingston DataTraveler 2GB USB
And it has been stable for the two weeks I've had it online and I get no pauses or jitter effect when watching a DVD streamed across my network to my XBMC PC. Yes, a new install but so far no problems. Temps stay below 40 degrees C even with all disks spun up and working. Seeing pretty consistent 7,900 MB/sec xor speeds.
So far very happy.