"when a peer is behind NAT or a firewall, it might wish to be able to receive incoming packets even when it is not sending any packets. Because NAT and stateful firewalls keep track of "connections", if a peer behind NAT or a firewall wishes to receive incoming packets, he must keep the NAT/firewall mapping valid, by periodically sending keepalive packets. This is called persistent keepalives. When this option is enabled, a keepalive packet is sent to the server endpoint once every interval seconds. A sensible interval that works with a wide variety of firewalls is 25 seconds. Setting it to 0 turns the feature off, which is the default, since most users will not need this, and it makes WireGuard slightly more chatty. This feature may be specified by adding the PersistentKeepalive = field to a peer in the configuration file, or setting persistent-keepalive at the command line. If you don't need this feature, don't enable it. But if you're behind NAT or a firewall and you want to receive incoming connections long after network traffic has gone silent, this option will keep the "connection" open in the eyes of NAT."
Source:https://www.wireguard.com/quickstart/
This is exactly my situation, my peer is not having a public IP due to ISP restriction. How do I configure persistant-keepalive in my Unraid Wireguard Peer setting?