I arrived into this discussion from another angle, but I thought i'd add to it:
I basically work as a PC tech, so I keep buying random flash drives to move stuff about and occasionally to reinstall OS's on random stuff I need to test or play with.
I have a tendency to just go "to a local store" and around here in Australia it's places like Kmart, Coles, Woolworths.
Kmart has Verbatim USB Drives, and I have a bunch of sizes from different times, largest is a couple of 64GB (because they went on sale) and they booted fine on what I have just laying on a desk right now (Core 2 Quad 6600 socket 775, on a Gigabyte G31M-S2L) and also was booting on 3 other customer machines (various ages) I did recently, and it boots on my TUF X470-Plus AMD mobo.
My motto has basically been that local stores like Coles/Kmart have a 1Y "no fuss" replacement policy on cheap items, so when it comes to things like USB drives I can just buy a single one, do a bunch of tests for my needs - ie boot drives for installations - and if they work, go back and buy a bunch, and easily get it replaced if one RNG fails - they wont even blink funny as long as you have BOTH the packaging AND the receipt - within the 1Y warranty. I mean, every 1-2 you will find a drive twice the size at the same price, so why not get them if you have uses for them.
If I decide to run Unraid (I'm thinking about it) id just have the "live stick" in all the time and I'd back it up to a removable clone (keep it unplugged to make it last longer) and just swap it in if I get an RNG failure on the live one. Get another stick to replace the dead, rinse and repeat.