I'm having the same problem as octomobiki and JoshuaH15 I'll wait and hopefully it resolves on its own. (update) the issue resolved after 3 or so hours, it must have been database migration. I guess this time it just took longer than usual so I noticed when I went to use Plex. I wonder why I didn't get the <Response code="503" title="Maintenance" status="Plex Media Server is currently running database migrations."/> message when I tried to access the web UI. That is much more helpful than the connection refused error I got.