Solutions
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clyde's post in HP MicroServer Gen10 - Freezes was marked as the answerCan be closed. So it was maybe macvlan change to ipvlan. Or the IOMMU change.
But I would bet on macvlan to ipvlan change right now - NIC is iirc a broadcom NetXtreme BCM5720NIC.
Just as reference if anybody maybe expierence same issues.
Thx for help JorgeB!