I'm in the middle of switching from an old generic case with an icy-dock 5-in-3 (awful cooling - can't recommend)) to a DS380 from Silverstone with an
ASRock Z390M-ITX/ac MB (6 SATA onboard + PCIe x4 M.2, one PCIe x16, 2x Intel 1000bt + wifi). One advantage I just found out about is that the HD trays are powered by a 4 pin Molex and I just confirmed that there is no 3.3v on the power bus for the rack. That means no messing with the pin-bypass hack on shucked drives - it's not powered in this system.
I'm not sure about the cooling as I've not run it full of disks (SoonTM), but the placement of fans is good. The only issue I can see is that, while one side of the 8x bay is covered with two large fans, the opposite side is the sliding case is flush, so the drive fans pressurize the case and the rear fan draws that air from the drives, over the CPU cooler, then out. I'm running an i5-9400 with the stock cooler and it's about 4x the CPU I need, so I don't expect it to be an issue.
The unit is reasonably quiet with the three fans running. The PS (300W Silverstone Bronze/80) hasn't fired up the fan yet (it's fanless at idle), but I'm just working through a memory test with no drives.