I am getting popups like seen in the attached screenshot. I have to click OK 10-20 times before the popup goes away (each popup with a call to a different function) and the webGUI is no longer working properly. What could be the issue?

 

Assuming that is your Unraid server IP

 

Make sure you have no other browsers open to the Unraid webUI, including mobile apps.

 

Try clearing browser cache. What browser are you using?

Obviously CA issue.  Make sure it's up to date.

Using Chrome. Allright, will try to update CA.

Upshot though is that under certain circumstances when that alert pops up (and it never should ever), it is possible (depending upon why it showed up) that the webGUI will not allow you to switch tabs away from Apps, and you're forced to reload the GUI in a new tab.  Updating to change that behavior.