+1 for this issue on macOS. I successfully configured WireGuard and tested it using an LTE hotspot: WireGuard registers a "handshake" as well as sent/received packets, but I cannot see any devices on the LAN or point my browser to the the web GUI at UNRAID.local or 192.168.xx.xx (or the newly assigned range).
Any suggestions?
*** EDIT ***
I also ran into configuration issues with WireGuard on pi-VPN, so, I set up an openVPN server with pi-VPN and that has worked perfectly. Ideally, I would be able to run WireGuard from Unraid, so I will keep working on this problem.