It wasn't spread over multiple disks. I still have installed it to disk1 to see if this helps, unfortunately not.
Could this be related to the combination of Wine and AMD?
UPDATE: After several automatic reboots, the server seems to be up and running now. I'll check if I can connect.
UPDATE2: It is working Thanks for your time ich777.
I have updated to 6.10.1, unfortunately the problem remains.
No changes have been done to the template, no cache disk installed.
I'm using a AMD Ryzen 5 3400G as CPU.