Okay, so to update you on this:
Booting into GUI mode produced no video output from the GPU, however I was able to monitor progress via iLO. After loading SMB, it get stuck on a flashing cursor. The webpage does still work via a browser. I logged in, checked the plugin, and saw that it was displaying a GPU ID and that nvidia-smi was working still. However, seconds following this, the web UI became completely non-functional and refused to load pages. I tried to perform a graceful reboot via iLO but it errored out (attached a screenshot of it). It hung here for several minutes before I had to forcibly reboot the system.
Booting back into non-GUI mode works fine, but the plugin ceases to work. It did cause a parity check to be started, but no big deal.
Two things to note: This is a fresh unRAID install (less than a week old) and switching to legacy 470.XX drivers resulted in the same issue.
Super weird, right?