I had similar problem,
Whenever I wanted to use my front usb with my usb headset I get to hear a lot of static noise.
This comes from bad isolated wires/bad wires/connector, I fixed my issue by temporary using the back used which are directly connected to the motherboard and then I changed the wire in the whole case which fixed my problem.
It might also affect any kind of data transmission in those USB.
(It also caused me issues when I connected USB keys in the past.)