Follow up on this topic. I changed a lot of settings ~1 month ago and I haven't had any issues since then.
Actions I took:
Deleted preclear plugin (I don't think this had any effect)
Deleted Tips & Tweaks plugin (I don't think this had any effect)
Deleted Nerds plugin (I don't think this had any effect, it wasn't suppose to be used anyways)
Dynamix File Integrity
I set to disabled: "Automatically protect new and modified files:"
Allowed incremental (not only full and differential) backups with Macrium
Allowed writing backups to cache drive
This couldn't be done with Acrium because they file into a single large file, while Macrium creates a new file for every backup
I believe the Dynamix File Integrity changes or directing backups to cache drive fixed the issue. But because I decided to go nuclear and try everything once, then I can't be sure.
