I get same problem also. New array. My 8 2TB drives precleared without issue, but my 4 4TB drives all get this same error (FAIL: unRAID's Preclear signature not valid.). Already tried: swapping cables, connecting to a different HBA card, rerouting power cables, clearing the drives with diskpart on W10 pc, turned off aggressive sata power management etc. no changes. Still fail on all 4TB drives.
Went through extended smart test. All came back clean. Seems to be working fine when I form an array with all the disks. still worries me tho, whether i still have some issue with the drives, cables or the HBAs whether or not to trust the array with current situation.
The 2TB drives (WD BLACKS and RE) came from old exsi -server, and 4 TB:s came from old Lenovo NAS. 2 of the 4TB drives are shucked and 2 are non-shucked retail WD RED:s.
Other than the size, only thing i can think of is that the 4TB drives were originally GPT -partitioned drives, whereas the 2TB:S were MBR. That shouldnt matter though?