I can confirm that the Proton version of the DS runs better than the Wine setup, at least on my setup with 2-3 players.
With a AMD Ryzen 5 2400G and 32GB of RAM we had some server load warnings, rubberbanding and lag while using the Wine version.
Switching to Proton and everything plays flawless with 3 players.
Switched back to Wine to confirm and performance was worse again with only 2 players.
I guess on lower spec servers the Proton version runs better while on high end servers its maybe not so noticeable.