I too have been following this thread with interest and doing a lot of googling for an unRAID build using a Norco 4224 later this year.
I'm torn between setting up a low-power ESXI SAN using openfiler and unRAID and a separate ESXi box for VMs - or trying to get everything working in one box. As I'm probably going to be using 3 PCI-E slots to get the openfiler/unRAID setup working (8 + 16 drives) a separate ESXi box would leave more room for tv tuner cards and other things, but something like this probably has enough space for everything.
I know that when a PCI device is passed through to a VM in ESXi, all other devices on the same bus are also passed through. Is this an issue for PCI-e? Are PCI-e slots (1x, 4x, 8x, 16x) always on their own bus? (is a "pci-e lane" a bus?)
I'm still confused about exactly what works and what doesn't with 1068e cards (passthrough, spindown/up, temperatures, serial numbers) - these seem to be the cheapest option so it would be nice to get these working properly.