This thread made me try out unRAID on a newly purchased QNAP TS-453D. I hooked up a monitor and keyboard, held down F2 during startup to enter BIOS, changed boot order to make 'UEFI: my usb drive" first and it worked beautifully. As far as I can tell unRAID recognizes all hardware correctly, except for the fan, but that is set to "auto" in BIOS (and it's spinning), so I think it doesn't matter. I'm very pleasantly surprised!