For whomever this might help- my network config was eff'd up in some way. At one point I had a 4 port network card (bond) and later removed it. The entries were still present in /boot/config/network.cfg. It did not seem to cause an issue until today. I did notice on rebooting my server that it would attempt to load the adapters and fail. I never thought much of it...but it must have caused an issue today. Perhaps this was exasperated by me changing the network setting for Docker to macvlan. I understand this has caused issues where the GUI would not load.
Either way- I deleted the network.cfg file after testing & removing the recently updated plugins that may have caused an issue. (I added them back before deleting) This resolved the issue for me. I did set macvlan BACK to ipvlan in GUI safe mode in my troubleshooting prior to the delete. Not sure if that helped our not. I changed that initially to troubleshoot issues with a docker communicating to another docker image.
dja's post in NVIDIA GPU passthrough locks UNRAID GUI on start was marked as the answer