Hey bastl, thanks for your reply. Obviously I should have explained it in more detail... It's not that the software won't work. However, it does not accept a license for a virtual machine. It would work with a license for a physical machine, but the licenses for a VM are much cheaper. It's all about the license costs.
The software is Acronis Cyber Backup which is used to back up special files from a database. In order to be able to work at the file level, the software needs an agent on the VM. The host system and the VM itself do not have to be backed up via the software - so there is no software installed on the host system. In such a use case, the agent on the VM checks what kind of system it is, informs the cloud console (also license server) and is provided with a corresponding license. In this case, unfortunately, this does not work because, as I now know, only the CPU ID flags are used as a criterion to check whether it is a VM or not.
Knowing this, the question for me was whether it would be possible to switch to Quemu64 with an existing system without any problems and what disadvantages or perhaps advantages this would bring.