There are several things to consider with cache and speed. Cache (or additional pools with 6.9), your Dockers and VMs are usually configured to use that space for performance, and so array disks can spin down. Cache is also used to cache user share writes to be moved to the slower array later.
Often people will disturb connections when replacing a disk and dual parity can sometimes help with that. And, sometimes another disk will actually begin to have problems while rebuilding another disk. Be sure to setup Notifications to alert you immediately by email or other agent as soon as a problem is detected. Unraid monitors SMART for all disks (unless you try to use RAID controller, don't).