appdata, domains, and system are normally kept on cache so your docker and VM performance won't be impacted by the slower parity writes on the array, and so your dockers and VMs won't keep array disks spinning.
Of these 3 shares, I would say system is the most important to keep on cache, because it is always in use if you have Docker and/or VM Services enabled.
You will have to disable Docker and VM Services since Mover can't move open files, then set system share to cache-prefer and run Mover to get it moved to cache where it belongs.
You can check how much of which disks each of your Shares are using by using the Compute All button on the Shares page.