That shouldn't matter. The only thing is to try and wait a couple of minutes longer than what you've been doing. Quirk of the GUI is that until everything is started up it won't respond. Myself, I've got user scripts installed with a script set to run at array start that is nothing but
beep
beep
beep
so that I know after a reboot when the system "thinks" it's up and running and then I know to wait a minute or two after those beeps before trying the WebUI
The troubleshooting from here is a pita, but it's renaming all the .plg files to be .plg1, reboot, then rename one of them back to .plg and reboot until the problems start again. The last one renamed is the culprit.
(It's on a mental todo list to kinda automate this via a plugin at some point)