I don't usually transfer files that large, though files of about 50GB I use quite frequently and never had issues, but for sure don't have a problem transferring various TBs over SMB with btrfs send/receive, that's a continuous stream, last one took almost 24 hours, without any issues, memory usage doesn't go above 20% with 16GB installed, if no one else has any ideas I'll do some tests with a 100GB file over the weekend.
Edit: I forgot I have screenshot from the last one I took because of an unrelated issue, and it was 17hours, not 24.