It is unlikely to be the Nvidia plugin as all that does is control whether the Unraid OS files on the USB stick that are the standard version should be replaced by the version that includes the Nvidia drivers. This replacement will only happen at the time you load a new version via the Nvidia settings - it will not have any affect the rest of the time as once a version is loaded onto the USB stick it boots just like the standard Unraid.
As was mentioned it is likely that the USB stick going offline for some reason caused the problem and rebooting fixed this. I guess there could be an inherent fault in the version of Unraid OS that the Nvidia plugin has installed, but this seems unlikely or more people would be having the same problem.