Btrfs is very susceptible to RAM or any other hardware corruption issue, much more than other filesystems, so if there's an issue it's where you'll see it first, but there are many users, not just in Unraid, using very large btrfs filesystem for years without issues, I myself have roughly 200 btrfs filesystems in use for about 5 or 6 years, only had issues with one, it got trashed twice in a couple of months, traced it to a bad disk.