Depends on your use case, and how your files are currently distributed, and how you want them to be distributed in the future. Unraid doesn't care, and as long as you have proper minimum free space limits set, you'll never see a meaningful difference using the shares.
It's purely an artificial need to organize things, but the benefits for most users lie on the side of letting drives fill up as they add them. That way the new files are all on a single drive, as most folks tend to use new files heavily then let them alone for archival reasons.
However, if you are like some people, me included, that micro manage which files go on which physical disks, then sometimes you need to move files from disk to disk to free up space for new files that "belong" on a specific disk.
That's why I asked the question, because unless you know a specific reason to move files, you probably don't really need to.
Every file operation incurs risk from user error or other things, so the less you muck around, the safer your data is, generally speaking.