No experience with that exact scenario, but my gut feeling is that Unraid will happily set up whatever you tell it to, the only issue would be that the motherboard may try to manipulate the disks and undo what unraid has done.
Since it's a new setup with zero data to lose, now is the ideal time to perform the experiment if you want. Just be prepared to redo it in Unraid after you reboot if removing the disks from the BIOS RAID does mess it up.
If I were you, I'd take the opportunity to learn. Set up the pool, confirm it's working, check the BTRFS stats and info on it, reboot and remove the disks from the BIOS RAID, and do a btrfs file system check after you boot back into Unraid. It's good to know how to keep up with the health of a BTRFS RAID volume on Unraid anyway, currently the stock setup isn't as thorough with BTRFS health checks as it should be.