On my Win 10 VM I run nicehash using my GTX 750ti, not a lot of money to be made but most of the time that VM is not used.
I have a FX-6300 6 core CPU on the unraid system, using core 5&6 for the VM. With nicehash running, the VM is sometimes sluggish to to point I need to stop mining while I need to use Win 10.
I am not about to buy a GTX 1080ti either.
If you are mining always keep your key backup file and paper copy. In April 2013 I transferred $5 from mining.bitcoin.cz pool to my wallet. I stopped mining, lost key for wallet, now that is worth $325. Too bad eh?