Yes, formatting a disk removes the 'clear' signature.
Not a good idea unless you actually want to use it via UD in the meantime for storing data. If you have formatted the drive in UD, then when you later try to add it to the parity protected array, unRAID will go through its clear process wiping existing contents and then on completing the clear expect you to format it from within unRAID.
this would be the recommended approach in most cases. The format from from within unRAID only takes moments, it is the long 'clear' step that is avoided by having it pre-cleared.