It can be, but the process to get the files moved after the fact is more work than simply setting them up there in the first place. Not a huge deal, but it feels like we have to walk someone through the process at least once a week and it gets old. It really is no more complex than disabling the docker and vm services then changing the settings and running the mover, but it seems like people have a hard time following explicit directions for some reason.
The biggest reason to have a SSD cache is to keep all the random accesses for containers and VM's fast, and allow the parity and data drives to spin down periodically. No cache means parity and at least one data drive spun up whenever the server is running.
Which computer? Unraid has to be ethernet hard wired into something that has an internet gateway, maybe describe your device topology a little more clearly?
So, you have 5 2TB drives with data currently? How long has it been since they have been health checked? I stand by my original suggestion to start with new drives, but it sounds like you could get away with a pair of 8TB, one parity, one data, and your 2 spare 2TB all formatted XFS, and copy the data from the ReiserFS drives leaving them for backup.
Not touchy, just complex. Too many variables in technology and world markets at the moment.
If you like to tinker and dig around for solutions and stuff, AMD seems to have a better performance for the price, but you may be chasing gremlins. Intel seems safer and more stable but cost more.
There is no such thing as being over prepared for VM's and containers, it's just a matter of capacity. It's "easy" to set up a single VM with hardware passthrough and a dozen or so docker containers, it's a whole 'nother thing to set one up with 3 simultaneous VM workstations all with their own monitor keyboard and mouse and 30+ docker containers. If you are shooting for the latter, better find someone who has already done it and copy their build, because it's going to require a specific recipe of server grade board and video cards.