Unraid doesn't run from the USB, it's only used at boot time to unpack the OS into RAM and read the saved settings. If properly managed, the USB stick is very reliable, there are many examples of 10+ years of service, moved from system to system as needed for motherboard upgrades.
A full sized USB 2.0 stick of 32GB capacity is ideal.
In the rare event of failure, it's simple to take the latest backup and create a new stick, as soon as Unraid gets online it will prompt you through the license replacement process.