Sorry, know nothing about Audio Workstations and their processing abilities and requirements.
Are they designed and capable of taking advantage of all available to a VM cores?
That's something that you'd need to look into specifically without making assumptions.
You haven't mentioned that software in your original post hence my understanding that you don't plan on anything particularly intensive.
If you plan on stressing your CPU to the fullest, with minimal acoustical noise then yeah, the use of AIO would be justified.
btw, modern HDDs when in use can also generate quite a bit of noise on their own.
Also, no need for an expensive multi-rail PSU (be quiet! straight power 11)